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SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.6
USERS' SCORE
Good
Based on 10 Reviews
8.9
Supplement Facts
Serving Size: 1 Spray (Approx. 0.41 ml)
Amount Per Serving
%DV
Vitamin B12(as Methylcobalamin from Saccharomyces cerevisiae)
500 mcg
20,833%
Certified Organic Food BlendOrganic Beet (root), Organic Carrot (root), Organic Spinach (leaf), Organic Broccoli (flower & stem), Organic Tomato (fruit), Organic Kale (leaf), Organic Cabbage (leaf), Organic Parsley (leaf), Organic Brussels Sprout (leaf), Organic Green Bell Pepper (fruit), Organic Cucumber (gourd), Organic Celery (stalk), Organic Garlic (bulb), Organic Ginger (root), Organic Onion (root), Organic Cauliflower (flower & stem), Organic Asparagus (flower & stem), Organic Strawberry (fruit), Organic Cherry (fruit), Organic Blackberry (fruit), Organic Blueberry (fruit), Organic Raspberry (fruit)
2 mg
+
Top Medical Research Studies
0
Vitamin B12 ineffective for CFS
N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.
Direct evaluation of treatment effects
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
Read More
8
Vitamin B12 drops show promise
Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders.
Direct investigation of B12 treatment
We examined the impact of vitamin B12 nasal drops on individuals suffering from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Our study involved fifty-one patients, predominantly female, with an average age of 42 and an average illness duration of 16 years.
After three months of treatment, we measured their vitamin B12 serum levels, physical activity, and fatigue and concentration levels. Interestingly, we found that the participants who responded positively to the treatment experienced significant improvements in their vitamin B12 levels, daily step count, and overall physical activity. Moreover, those who reported a positive response noted a decrease in fatigue levels.
On the flip side, those categorized as non-responders had only a modest increase in vitamin B12 levels, with no notable improvement in other measures. Overall, our findings suggest that nasal drops could serve as a viable alternative to vitamin B12 injections, especially since around two-thirds of participants reported feeling better after treatment. This pilot study opens up new avenues for interventions in managing ME/CFS and highlights the importance of considering alternative treatment methods.
After three months of treatment, we measured their vitamin B12 serum levels, physical activity, and fatigue and concentration levels. Interestingly, we found that the participants who responded positively to the treatment experienced significant improvements in their vitamin B12 levels, daily step count, and overall physical activity. Moreover, those who reported a positive response noted a decrease in fatigue levels.
On the flip side, those categorized as non-responders had only a modest increase in vitamin B12 levels, with no notable improvement in other measures. Overall, our findings suggest that nasal drops could serve as a viable alternative to vitamin B12 injections, especially since around two-thirds of participants reported feeling better after treatment. This pilot study opens up new avenues for interventions in managing ME/CFS and highlights the importance of considering alternative treatment methods.
Read More
7
Potential benefits of yeast supplements
[Biologically active food additives for correction of the chronic fatigue syndrome].
Moderate relevance score
We explored the impact of "Nagipol," a supplement made from beer yeasts, on chronic fatigue syndrome (CFS). Our clinical study indicated that "Nagipol" could improve the clinical status of CFS patients. It appears to help enhance cognitive functions and stabilize emotional symptoms while also normalizing certain blood parameters.
While these findings are promising, it’s important to note that further research is needed to fully confirm these benefits, especially regarding its role in diet therapy for individuals dealing with CFS.
While these findings are promising, it’s important to note that further research is needed to fully confirm these benefits, especially regarding its role in diet therapy for individuals dealing with CFS.
Read More
Most Useful Reviews
9.5
Fatigue improvement
I find these vitamins effective. The vitamin B12 spray is convenient for children—no injections or pills needed. As I have low hemoglobin and do not eat meat, I thought these would benefit me. I experienced no allergies or gastrointestinal changes. My hair stopped falling out after a month, and the chronic fatigue syndrome vanished.
Read More
9
Better absorption
This liquid B12 is excellent. My child, with ASD, takes it sublingually in the morning, helping his vitamin B12 absorption. I ensure to check vitamin levels before taking supplements. Methylcobalamin is the most easily absorbed form. We've been using B vitamins for ten years; they greatly help with chronic fatigue syndrome and improve overall well-being.
Read More
9.5
Symptoms relieved
I was severely B12 deficient, leading to neurological issues that baffled my doctor. I researched and realised my symptoms related to B12 deficiency. After ordering the supplement, my symptoms improved in just two weeks. I'm not a vegetarian but have low meat intake. I continue taking high doses to recover from chronic fatigue syndrome.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.6
8
Vitamin B12 drops show promise
Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders.
Direct investigation of B12 treatment
We examined the impact of vitamin B12 nasal drops on individuals suffering from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Our study involved fifty-one patients, predominantly female, with an average age of 42 and an average illness duration of 16 years.
After three months of treatment, we measured their vitamin B12 serum levels, physical activity, and fatigue and concentration levels. Interestingly, we found that the participants who responded positively to the treatment experienced significant improvements in their vitamin B12 levels, daily step count, and overall physical activity. Moreover, those who reported a positive response noted a decrease in fatigue levels.
On the flip side, those categorized as non-responders had only a modest increase in vitamin B12 levels, with no notable improvement in other measures. Overall, our findings suggest that nasal drops could serve as a viable alternative to vitamin B12 injections, especially since around two-thirds of participants reported feeling better after treatment. This pilot study opens up new avenues for interventions in managing ME/CFS and highlights the importance of considering alternative treatment methods.
After three months of treatment, we measured their vitamin B12 serum levels, physical activity, and fatigue and concentration levels. Interestingly, we found that the participants who responded positively to the treatment experienced significant improvements in their vitamin B12 levels, daily step count, and overall physical activity. Moreover, those who reported a positive response noted a decrease in fatigue levels.
On the flip side, those categorized as non-responders had only a modest increase in vitamin B12 levels, with no notable improvement in other measures. Overall, our findings suggest that nasal drops could serve as a viable alternative to vitamin B12 injections, especially since around two-thirds of participants reported feeling better after treatment. This pilot study opens up new avenues for interventions in managing ME/CFS and highlights the importance of considering alternative treatment methods.
Read More
8
B12 may aid chronic fatigue treatment
Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.
Relevant score suggests moderate support
We explored the effects of frequent vitamin B12 injections in patients suffering from chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME). The study included 38 patients who received B12 injections at least weekly for a period ranging from six months to several years.
Our findings revealed two groups of patients: those termed "Good responders" and "Mild responders." Good responders, who reported feeling significantly better, used higher doses and more frequent injections of B12, alongside daily oral folic acid tailored to their individual needs.
Interestingly, the results indicated that Mild responders often relied on pain medications like opioids, which might interfere with B12’s effects. We noted that co-existing thyroid issues were common among these patients, suggesting a complex interaction at play.
Overall, our study points to a real potential benefit from vitamin B12 and folic acid in managing chronic fatigue symptoms. However, individual responses can vary greatly, and it’s crucial to consider each patient's unique circumstances when designing future clinical studies.
Our findings revealed two groups of patients: those termed "Good responders" and "Mild responders." Good responders, who reported feeling significantly better, used higher doses and more frequent injections of B12, alongside daily oral folic acid tailored to their individual needs.
Interestingly, the results indicated that Mild responders often relied on pain medications like opioids, which might interfere with B12’s effects. We noted that co-existing thyroid issues were common among these patients, suggesting a complex interaction at play.
Overall, our study points to a real potential benefit from vitamin B12 and folic acid in managing chronic fatigue symptoms. However, individual responses can vary greatly, and it’s crucial to consider each patient's unique circumstances when designing future clinical studies.
Read More
8
Potential effects on chronic fatigue
Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems.
Combination therapy complicates evaluation
We recently came across an intriguing study that highlighted the potential benefits of a combination therapy involving lofepramine, L-phenylalanine, and vitamin B12 for patients suffering from multiple sclerosis (MS). Conducted as a randomized, placebo-controlled double-blind trial, the research aimed to evaluate how this combination could help alleviate various symptoms associated with MS and chronic pain.
While this study did address the role of vitamin B12, it was examined alongside lofepramine and phenylalanine. This makes it challenging for us to pinpoint the specific impact of vitamin B12 in the context of chronic fatigue syndrome on its own. The treatment showed effectiveness in improving symptoms within just two to four weeks, but due to the combination of treatments, we need more focused studies to assess vitamin B12's distinct role.
Overall, it's exciting to see a potential link between this therapy and symptom relief, yet we must remain cautious about attributing the benefits solely to vitamin B12, given the blended approach of the therapy used in the trial.
While this study did address the role of vitamin B12, it was examined alongside lofepramine and phenylalanine. This makes it challenging for us to pinpoint the specific impact of vitamin B12 in the context of chronic fatigue syndrome on its own. The treatment showed effectiveness in improving symptoms within just two to four weeks, but due to the combination of treatments, we need more focused studies to assess vitamin B12's distinct role.
Overall, it's exciting to see a potential link between this therapy and symptom relief, yet we must remain cautious about attributing the benefits solely to vitamin B12, given the blended approach of the therapy used in the trial.
Read More
7
Beta-glucan alleviates cognitive fatigue
Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
Study findings warrant further exploration.
We conducted a rigorous 36-week study with 65 patients diagnosed with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Participants were given either yeast-derived beta-glucan with vitamins or a placebo.
The results revealed that those taking beta-glucan showed notable improvements in cognitive fatigue compared to those on the placebo. This suggests that beta-glucan could be a promising nutritional supplement for easing cognitive symptoms associated with ME/CFS.
However, more research is needed to fully understand its benefits and mechanisms.
The results revealed that those taking beta-glucan showed notable improvements in cognitive fatigue compared to those on the placebo. This suggests that beta-glucan could be a promising nutritional supplement for easing cognitive symptoms associated with ME/CFS.
However, more research is needed to fully understand its benefits and mechanisms.
Read More
7
Potential benefits of yeast supplements
[Biologically active food additives for correction of the chronic fatigue syndrome].
Moderate relevance score
We explored the impact of "Nagipol," a supplement made from beer yeasts, on chronic fatigue syndrome (CFS). Our clinical study indicated that "Nagipol" could improve the clinical status of CFS patients. It appears to help enhance cognitive functions and stabilize emotional symptoms while also normalizing certain blood parameters.
While these findings are promising, it’s important to note that further research is needed to fully confirm these benefits, especially regarding its role in diet therapy for individuals dealing with CFS.
While these findings are promising, it’s important to note that further research is needed to fully confirm these benefits, especially regarding its role in diet therapy for individuals dealing with CFS.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.9
9.5
Fatigue improvement
I find these vitamins effective. The vitamin B12 spray is convenient for children—no injections or pills needed. As I have low hemoglobin and do not eat meat, I thought these would benefit me. I experienced no allergies or gastrointestinal changes. My hair stopped falling out after a month, and the chronic fatigue syndrome vanished.
Read More
9.5
Symptoms relieved
I was severely B12 deficient, leading to neurological issues that baffled my doctor. I researched and realised my symptoms related to B12 deficiency. After ordering the supplement, my symptoms improved in just two weeks. I'm not a vegetarian but have low meat intake. I continue taking high doses to recover from chronic fatigue syndrome.
Read More
9
Better absorption
This liquid B12 is excellent. My child, with ASD, takes it sublingually in the morning, helping his vitamin B12 absorption. I ensure to check vitamin levels before taking supplements. Methylcobalamin is the most easily absorbed form. We've been using B vitamins for ten years; they greatly help with chronic fatigue syndrome and improve overall well-being.
Read More
8.8
Fatigue reduction
My vitamin B12 levels have been borderline for years, leading to fatigue and irritability. I searched for an easy-to-use supplement and opted for this convenient spray. After two weeks, my fatigue began to diminish. I look forward to retesting my levels in a month, as I previously had slightly low results.
Read More
8.8
Increased energy
We are a vegetarian family, and this product effectively addresses our B12 deficiency. My levels were critically low, causing chronic fatigue syndrome and other issues. I found this spray preferable to injections. After a month, my B12 levels improved, enhancing our overall energy and well-being.
Read More
